MyBioSource.com's Rabbit anti-Human immunodeficiency virus type 2 subtype A Protein Vpx polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA. The Rabbit anti-Human immunodeficiency virus type 2 subtype A Protein Vpx polyclonal Antibody was generated using HIV2gp3 as the antigen and it reacts with Human.
Description
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription